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To independently ensure the position of SAC in cell killing by LY2523355, we silenced SAC protein Mad2 by siRNA. As compared Along with the parental cells, cells with silenced Mad2 did not be arrested at mitosis and Therefore had no activated caspase action, indicating that SAC has an essential function in mitotic arrest and subsequent cell killing… Read More


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If person, he is infertile, vasectomized (i.e. who has gained health-related evaluation with the surgical good results) or agrees to abstain from or to use a condom through heterosexual intercourse with a girl of childbearing possible or simply a Expecting girl, and agrees not to donate sperm, from investigational item administration until eventual… Read More